Summary: The new results of the vital vital trial show that daily supplementation in vitamin D3 helps preserve the length of telomeres in the elderly, potentially slowing down a key biological aging process. Telomeres are protective ceilings on chromosomes that are shortened with age and are associated with chronic diseases.
For four years, those who have taken vitamin D experienced much less shortening of the telomeres, equivalent to almost three years of delayed aging, compared to those who took a placebo. These results support vitamin D as a promising intervention to reduce age -related cell decline, although more research is needed to confirm long -term advantages.
Key facts:
- Anti-aging effect: Vitamin D3 supplementation has slowed the shortening of telomeres over 4 years.
- Cell protection: Participants have kept the equivalent of 3 more health of telomeres.
- No effect of omega-3: Omega-3 supplementation did not have a significant impact on the length of the telomeres.
Source: Mass general
The results of the vital vital controlled trial reveal that the supplementation of vitamin helps to maintain telomeres, protective ceilings at the ends of chromosomes which are shortened during aging and are linked to the development of certain diseases.
The new report, which is published in The American Journal of Clinical Nutritionis based on the data of a vital sub-study co-directed by researchers from the mass general Brigham and the Medical College of Georgia, and supports a promising role in the slowdown in a path for organic aging.
“Vital is the first randomized large-scale and long-term trial to show that vitamin D supplements protect the telomeres and preserve the length of the telomeres,” said co-author Joann Manson, MD, principal investigator of Vital and chief of the Division of Preventive Medicine of Brigham and Women’s Hospital, founding member of the Mass General Brigham health system.
“This is of particular interest, because Vital had also shown the advantages of vitamin D to reduce inflammation and reduce the risk of selected chronic selections of aging, such as advanced cancer and autoimmune diseases.”
Telomeres are made of repetitive DNA sequences or base pairs which prevent the ends of chromosomes from degrading or fusion with other chromosomes. The shortening of telomeres is a natural element of aging and is associated with an increased risk of various age -related diseases.
Some short -term short -scale studies have suggested that vitamin D or omega 3 fatty acid supplementation can help support telomeres, but the results have been incoherent.
Vital is a randomized double blind and controlled trial on placebo on fatty acid supplementation (1 g / day) (2,000 IU / day) and omega 3 (1 g / day) which followed American women aged 55 and over and men aged 50 and over for five years.
The sub-study of vital telomeres included 1,054 of these participants, whose length of the telomeres in the white blood cells was evaluated at the start and at 2 and at year 4.
Compared to the taking of placebo, taking vitamin D3 supplements has considerably reduced the telomeres which are shortened over four years, preventing the equivalent of almost three years of aging compared to the placebo. Omega 3 fatty acid supplementation had no significant effect on the length of the telomeres throughout the follow -up.
“Our results suggest that targeted vitamin D supplementation can be a promising strategy to counter a biological aging process, although additional research is justified,” said Haidong Zhu, PHD, the first author of the report and molecular geneticist at Medical College of Georgia, Augusta University.
Paternity: In addition to Manson, the authors of the mass general Brigham include Nancy R. Cook, William Christen and I-Min Lee. The additional authors include Haidong Zhu, Bayu B. Bekele, Li Chen, Kevin J. Kane, Ying Huang, Wenju Li and Yanbin Dong.
Disclosure: The authors declare that they have no financial interests or known personal relationships which could have seemed to influence the work reported in this article.
Funding: This work was supported by the National Heart, Lung and Blood Institute (R01 HL131674-01). The Parent Vital Essay is supported by R01 AT011729. The study donors of the study had no role in the design of the study, data collection, data analysis, data interpretation or reporting of the report as well as in the decision to submit the document for publication.
About this aging research news
Author: Alexandra Pantano
Source: Mass general
Contact: Alexandra Pantano – Mass general
Picture: The image is credited with Neuroscience News
Original search: Open access.
“Vitamin D3 and supplementation of omega-3 sailor omega-3 fatty acids and leukocyte telomeres: 4 years of the vital randomized controlled trial” by Joann Manson et al. American Journal of Clinical Nutrition
Abstract
Vitamin D3 and Marine supplementation with omega-3 fatty acids and leukocyte telomère Length: 4 years of the trial controlled trial randomized vital
Background
Limited studies suggest that supplementation in vitamin D or omega 3 fatty acids (N-3 FAS) can be beneficial for the maintenance of telomeres, however, the evidence of large randomized clinical trials are lacking. We hypothesized that the supplementation in vitamin D or N-3 FES reduced overtime to the attrition of the length of the telocytes (LTL) by taking advantage of the test test in vitamin D and omega-3 (vital).
Methods
Vital is a large randomized, double blind, placebo -controlled trial with a factorial design of 2 x 2 of vitamin D3 (2,000 IU / day) and N-3 FAS marine supplements (1 g / day) for 5 years among a representative sample of 25,871 American women ≥ 55 and men ≥ 50 years. The study of vital telomeres (NCT04386577) included 1054 participants who were evaluated in person at the Harvard Clinical and Translational Science Center.
The LTL was determined by the method of reaction in quantitative chain in polymerase chain (PCR) of quantification of human human length at the basis of the basis, the 2nd year and the year 4. Pre-special primary result measures have been changes in the LTL between the linear regression models of the basic mixed effects, the analyzes of the used intervention effect.
Results
The LTL was measured in a total of 2,571 samples of the 1031 participants at the start, of the year 2 and the year 4. compared to the placebo, vitamin D3 Supplementation has significantly reduced LTL attrition of 0.14 kilo base pairs (KB) (0.01, 0.27) over 4 years (p = 0.039).
Global trend analysis has shown that vitamin D3 The supplementation group had LTLs which were approximately 0.035 kb more per year of follow -up compared to the placebo group (0.002, 0.07, p = 0.037). Marine n-3 FAS maritime supplementation had no significant effect on the LTL for two years 2 or 4th year.
Conclusion
4 years of supplementation with 2000 IU / Vitamin D day3 Reduced attrition of 140 bp telomeres, suggesting that vitamin D3 Daily supplementation with or without N-3 FAS could play a role in the thwart of the erosion of telomeres or cell senescence.
