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Source: Cardinals’ Kyler Murray expected to miss vs. Colts

David Miller by David Miller
October 12, 2025
in Sports
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  • Josh WeinfussOctober 11, 2025, 11:30 p.m. ET

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      Josh Weinfuss is a writer who covers the Arizona Cardinals and the NFL on ESPN. Josh has covered the Cardinals since 2012 and joined ESPN in 2013. He is a member of the Pro Football Writers of America and a graduate of Indiana University.

Arizona Cardinals quarterback Kyler Murray is not expected to play Sunday against the Indianapolis Colts due to a foot injury suffered last weekend, a source told ESPN’s Adam Schefter and Jeremy Fowler.

Veteran backup Jacoby Brissett would start in Murray’s place at Lucas Oil Stadium, where Brissett played from 2017-2020.

Murray only practiced Friday after injuring his foot in a loss to the Tennessee Titans.

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Brissett has started 53 games in 10 seasons and is 19-34 with 53 career touchdowns. His last start was in Week 5 of last season for the New England Patriots. Brissett started the first five games of the season and, after winning the first game of the season, lost the next four before being benched.

All week, even though they didn’t know who the starter would be, Brissett’s Arizona teammates expressed comfort with him at quarterback.

“I have full confidence in Jacoby,” said wide receiver Marvin Harrison Jr. “I think the biggest thing is he’s been a really good leader and mentor to me since he got here.”

Harrison said he and Brissett worked together after practices before Murray’s injury to free up Brissett’s arm and take shots he didn’t have in practice as a backup.

Harrison added that the two developed a rapport throughout their time together after practices.

Tight end Trey McBride said he felt “really good with” Brissett.

“I think Jacoby, obviously, has played a long time in this league,” McBride said. “He’s played for a lot of different teams. He’s played for a lot of different receivers, he came in in the middle of the season and he’s done everything. So he’s a guy that I have full confidence in and a guy that commands the huddle, understands what he’s doing, and he’s going to go out there and make plays and he’s going to do the right thing.”

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Tags: cardinalscoltsexpectedKylerMurraySource
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