For hundreds of years, humans have continued the secrets of aging with unshakable determination – decode our DNA, analyze free radicals and test so -called miracle compounds – in the hope of slowing down, stopping or even reversing the passage of time.
Scientists have explored everything, from caloric restriction to genetic publishing, employing strategies as ambitious as they are diverse. However, aging continued its stable and inflexible course.
Now researchers are taking a new daring direction. Instead of focusing only on how we live, they study how we die.
They focus on something called “necrosis” – a violent and uncontrolled form of cell death Biological wreckage – and discover your surprising potential to reshape the way we understand the disease, degeneration and the future of human longevity.
Necrosis disrupts healthy cellular function
Cells are generally renewed by controlled processes. This renewal helps to replace old cells and maintain functional tissues.
Necrosis occurs when cells die abruptly and uncontrolled, usually in response to injuries, infection or severe stress.
Unlike apoptosis, the body is carefully programmed cell death processNecrosis unleashes chaos. The cell swells, breaks and overturns its content in the surrounding tissues, triggering inflammation and damaging neighboring cells.
This destructive cascade often leads to chronic degeneration of diseases and tissues, especially when the body cannot repair the affected area.
A world team of scientists has examined the role that necrosis plays in many conditions related to age.
“No one really likes to talk about death, even of cell death, that is perhaps why the physiology of death is so badly understood,” noted Dr Keith Siewone of the authors of the study, originally from UCL Center for the Health of the Keeps of the Keeps and the bladder.
Kidneys of the kidneys, heart and brain
Renal problems Assign many people in their last years. This organ filters toxins, and when enough kidney cells die, there is more chance of requiring dialysis.
If necrosis is a major factor in the triggering of kidney lesions, targeting can allow healthier kidneys longer.
Research shows that at 75 years old, almost half of all individuals can suffer from a certain level of kidney disease.
Studies also suggest that necrosis can play a role in conditions such as heart disease and Alzheimer’s. When cell degradation releases harmful molecules, the surrounding tissues can be ignited.
While these fabrics fight, the effects can wave in the body. Even light inflammation can bring the body’s ability to repair himself.
Astronauts and necrosis
Space health experts Find interesting necrosis because the low gravity and cosmic radiation can impress human organs. Astronauts experience accelerated aging during long missions.
Kidneys are particularly vulnerable because reduced liquid regulation and exposure to radiation can affect the way they function.
The idea that the interruption of necrosis could protect these vital bodies has triggered new questions on maintaining the health of astronauts for prolonged travel.
“Targeting necrosis offers potential not only to transform longevity on earth, but also push the boundaries of spatial exploration,” said Professor Damian Baileyof the University of southern Wales And the Life Sciences Working Group of the European Space Agency.
Stopping necrosis can protect cells
“If we could prevent necrosis, even temporarily, we closed these destructive cycles at their source,” said Dr. Carina Kern, CEO of Linkgevity.
Some researchers think that if necrosis can be interrupted, it could stop a domino effect of tissue lesions. By preserving the cells that are on the verge of failure, the body would have a better chance of carrying out a self-repair.
One hypothesis suggests that maintaining calcium levels under control in cells could be essential.
Calcium Often acts as a switch, activating or deactivating important cellular functions. If too much enters a stressed cell, this cell can break. Scientists hope that the prevention of this wave could stop the degradation of large -scale tissues.
Improve quality of life
Age -related disorders Come with a loss of progressive but significant function. Necrosis appears in conditions affecting not only the kidneys, but also the brain, the heart and other organs.
When the cells burst and release debris, the surrounding tissues may undergo continuous inflammation. The interruption of this model could reduce suffering and add productive years for many people.
This approach could also allow doctors to solve several health problems at the same time. Rather than chasing each disease individually, limiting necrosis can allow the body to maintain its own balance.
As the population is aging, ideas like these could open new possibilities for health management and medical innovation.
Block pesting cell death
Researchers from around the world are studying if drugs blocking necrosis or genes -based therapies can be used safely.
They aim to determine whether these approaches can work without disturbing the beneficial types of cell death which eliminate defective or excess cells.
Tanging these processes could be delicate, but the concept of saving healthy tissue and preventing irreversible damage has drawn great attention.
With more teams that study these ways, the exploitation of necrosis control are developing. For the moment, public interest and continuous clinical trials can help clarify how this form of cell death can be effectively targeted.
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A special thank you to the clinicians of UCL medicine division,, Brigham and Women’s Hospital,, Mayo clinicand the European Space Agency.
The study is published in Oncogen.
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