Ohio State vs. Notre Dame plus/minus, spread, props: 2025 CFP National Championship game picks from top experts

The elite defenses will face off Monday night when Notre Dame takes on Ohio State in the 2025 College Football Playoff national championship game. The Buckeyes are seeking their first national title in 10 years after winning their first three playoff games by more than 14 points. They qualified for the championship with a 28-14 victory over Texas in the Cotton Bowl. Notre Dame is on a 13-game winning streak after victories over Indiana, Georgia and Penn State in the 12-team CFP.

Kickoff is scheduled for 7:30 p.m. ET at Mercedes-Benz Stadium in Atlanta. The Buckeyes are 9-point favorites in the latest Notre Dame vs. Ohio State odds via SportsLine consensus, while the over/under on total points scored is 45.5. There are also plenty of Ohio State vs. Notre Dame props available. For example, the over/under of total touchdowns scored in the game is 5.5. Before making any Ohio State vs. Notre Dame picks, you need to check out the College Football Playoff championship predictions and betting advice from SportsLine’s Jimmie Kaylor.

Kaylor is an NFL, college football and DFS expert for SportsLine, covering the NFL and college football for nearly a decade as a member of the Pro Football Writers of America. His experience as a former All-American and NFL college football player gives him a unique perspective when it comes to building his fantasy teams and locking in his betting picks. He has his finger on the pulse of the college football landscape and has won big on sports betting apps over the past two years.

Kaylor has destroyed sports betting in college football over the past two seasons, posting a record of 232-150-7 since the first week of the 2023 season. His 2024 college football futures picks included Travis Hunter winning the Heisman Trophy at 40-1 odds, bringing his net profit to 112.07 units ($11,206.50 for a $100 bettor) since that he joined SportsLine as an expert in 2023.

All of his picks have been featured on his SportsLine Experts page or in his weekly byline articles. Anyone who follows their betting choices could be ahead.

Now, Kaylor reached out to Notre Dame vs. Ohio State in the 2025 CFP National Championship Game and just revealed his picks and predictions. You can head over to SportsLine now to see his picks. Here are the college football odds and college football betting lines for Ohio State vs. Notre Dame:

• Notre Dame vs. Ohio State Spread: Ohio State -9
• Notre Dame vs. Ohio State plus/minus: 45.5 points
• Notre Dame vs. Ohio State money line: Ohio State -403, Notre Dame +312
• Notre Dame vs. Ohio State Picks: See the picks at SportsLine
• Stream Notre Dame vs. Ohio State: FuboTV (try free)

Notre Dame vs. Ohio State Expert Predictions

For the 2025 CFP Championship, Kaylor is over the total (45.5), despite this game featuring the two best defenses in college football. Ohio State has given up the fewest points per game (12.2) in the country, while Notre Dame is just behind the Buckeyes at 14.3 points per game.

There will be plenty of firepower in this game, however, as Notre Dame ranks sixth nationally in points per game (37.0) and Ohio State ranks 12th (35.8). The Buckeyes found another gear in the College Football Playoff, scoring at least 28 points in all three games. They topped the 40-point mark against Tennessee and Oregon, both of whom have top-20 defenses.

Notre Dame has topped 21 points in its three games, despite three elite defenses in Indiana, Georgia and Penn State. Both teams have experienced quarterbacks in this championship matchup, so Kaylor expects them to score in crucial situations. See which side to support here.

How to make choices between Ohio State and Notre Dame

In addition to going over, Kaylor also revealed his pick against the spread as well as two prop bets, including one that pays out over +300. He only shares his ATS pick and these prop bets on SportsLine.

So who wins Notre Dame against Ohio State in the College Football Playoff national championship game, and which props should you target for a big payday? Visit SportsLine now to see which props and which side to jump on, all from the expert who has profited $11,207 for $100 to college football bettors since Week 1 of the 2023 season, and find out- THE.