Bills quarterback Josh Allen will lose two weapons for Monday Night Football.
Tight end Dalton Kincaid (oblique) and wide receiver Curtis Samuel (neck/ribs) are inactive. Both were questionable to play against the Falcons.
Kincaid had limited practices every three days, and Samuel was limited to two days and out for one.
Kincaid is the team leader with 287 receiving yards and three receiving touchdowns on 24 catches, while Samuel contributed four catches for 35 yards and a touchdown.
Others inactive for the Bills are linebacker Matt Milano (pectoral), linebacker Jimmy Ciarlo and offensive lineman Chase Lundt.
The Bills elevated safety Jordan Poyer and defensive tackle Jordan Phillips from the practice squad for the game.
The Falcons will be without receiver Darnell Mooney (hamstring), receiver Ray-Ray McCloud III, cornerback Clark Phillips III (triceps/illness), running back Nathan Carter, cornerback Billy Bowman (knee/hamstring), defensive lineman LaCale London (triceps) and lineman offensive Jack Nelson.