Categories: Health

Lifetime risk and projected burden of dementia

  • Caplan, Z. The U.S. elderly population grew from 2010 to 2020 at the fastest rate since 1880 to 1890. United States Census Bureau. https://www.census.gov/library/stories/2023/05/2020-census-united-states-older-population-grew.html (2023).

  • Rajan, KB et al. Estimated population of people with clinical Alzheimer’s disease and mild cognitive impairment in the United States (2020-2060). Alzheimer’s dementia. 171966-1975 (2021).

    Article PubMed Google Scholar

  • Murphy, S., Kochanek, K., Xu, J., and Arias, E. Mortality in the United States, 2020. NCHS Data Brief, No. 427. National Center for Health Statistics. https://www.cdc.gov/nchs/data/databriefs/db427.pdf (2021).

  • Nandi, A. et al. Global and regional projections of the economic burden of Alzheimer’s disease and related dementias from 2019 to 2050: a statistical approach to the value of life. EClinicMedicine 51101580 (2022).

    Article PubMed PubMed Central Google Scholar

  • Facts and figures about Alzheimer’s disease in 2023. Alzheimer’s dementia. 191598-1695 (2023).

  • Seshadri, S. & Wolf, PA Lifetime risk of stroke and dementia: current concepts and estimates from the Framingham study. Lancet Neurol. 61106-1114 (2007).

    Article PubMed Google Scholar

  • Martin, SS et al. Heart Disease and Stroke Statistics 2024: A Report on U.S. and Global Data from the American Heart Association. Traffic 149e347-e913 (2024).

    Article PubMed Google Scholar

  • Chêne, G. et al. Sex and incidence of dementia in the Framingham Heart Study from midlife onwards. Alzheimer’s dementia. 11310-320 (2015).

    Article PubMed Google Scholar

  • Beiser, A., Au, R., McNulty, K., White, R. and D’agostino, R. Lifetime risk of dementia and Alzheimer’s disease: impact of mortality on risk estimates in the Framingham study. Neurology 491498-1504 (1997).

    Article PubMed Google Scholar

  • Licher, S. et al. Lifetime risk of common neurological diseases in the elderly population. J. Neurol. Neurosurgery. Psychiatry 90148-156 (2019).

    Article PubMed Google Scholar

  • Chatfield, MD, Brayne, CE and Matthews, FE A systematic review of the literature on attrition between waves in longitudinal studies in older adults shows a consistent pattern of dropout between different studies. J. Clin. Epidemiol. 5813-19 (2005).

    Article PubMed Google Scholar

  • Livingston, G. et al. Dementia prevention, intervention and care: 2020 report of the Lancet Commission. Lancet 396413-446 (2020).

    Article PubMed PubMed Central Google Scholar

  • Ngandu, T. et al. A 2-year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk older adults (FINGER): a randomized controlled trial. Lancet 3852255-2263 (2015).

    Article PubMed Google Scholar

  • van Charante, EPM et al. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster randomized controlled trial. Lancet 388797-805 (2016).

    Google Scholar article

  • Lin, FR et al. Auditory intervention versus health education control to reduce cognitive decline among older adults with hearing loss in the United States (ACHIEVE): a multicenter randomized controlled trial. Lancet 402786-797 (2023).

    Article PubMed PubMed Central Google Scholar

  • Coley, N., Giulioli, C., Aisen, PS, Vellas, B. & Andrieu, S. Randomized controlled trials for the prevention of cognitive decline or dementia: a systematic review. Aging Res. Round. 82101777 (2022).

    Article PubMed Google Scholar

  • Williamson, JD et al. Effect of intensive versus standard blood pressure control on probable dementia: a randomized clinical trial. JAMA 321553-561 (2019).

    Article PubMed PubMed Central Google Scholar

  • Lloyd-Jones, DM et al. Cardiovascular health status among US adults and children using the new American Heart Association “Life’s Essential 8” measures: prevalence estimates from the National Health and Nutrition Examination Survey (NHANES), 2013 to 2018. Traffic 146822-835 (2022).

    Article CAS PubMed Google Scholar

  • Reed, NS et al. Prevalence of hearing loss and hearing aid use among U.S. Medicare beneficiaries aged 71 and older. JAMA Network. Open 6e2326320 (2023).

    Article PubMed PubMed Central Google Scholar

  • Qian, J. et al. APOE-risk linked to mild cognitive impairment and dementia for prevention trials: an analysis of four cohorts. PLoS Med. 14e1002254 (2017).

    Article PubMed PubMed Central Google Scholar

  • Yamazaki, Y., Zhao, N., Caulfield, TR, Liu, C.-C. & Bu, G. Apolipoprotein E and Alzheimer’s disease: pathobiology and targeting strategies. Nat. Reverend Neurol. 15501-518 (2019).

    Article CAS PubMed PubMed Central Google Scholar

  • Fortea, J. et al. APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease. Nat. Med. 301284-1291 (2024).

  • Matthews, KA et al. Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015-2060) among adults aged ≥65 years. Alzheimer’s dementia. 1517-24 (2019).

    Article PubMed Google Scholar

  • Weuve, J. et al. Cognitive aging in black and white Americans: cognition, cognitive decline, and incidence of Alzheimer’s disease-related dementia. Epidemiology 29151 (2018).

    Article PubMed PubMed Central Google Scholar

  • Ferretti, MT et al. Gender differences in Alzheimer’s disease: the gateway to precision medicine. Nat. Reverend Neurol. 14457-469 (2018).

    Article PubMed Google Scholar

  • Ott, A., Breteler, MM, Harskamp, ​​FV, Stijnen, T. & Hofman, A. Incidence and risk of dementia: the Rotterdam study. Am. J. Epidemiol. 147574-580 (1998).

    Article CAS PubMed Google Scholar

  • Feigin, VL et al. Burden of neurological disorders in the United States from 1990 to 2017: a global burden of disease study. JAMA Neurol. 78165-176 (2021).

    Article PubMed Google Scholar

  • Vespa, J., Armstrong, D.M. and Medina, L. Demographic turning points for the United States: population projections for 2020 to 2060 (US Department of Commerce, Economics and Statistical Administration, US Census Bureau, 2018).

  • Wilkinson, T. et al. Identifying cases of dementia with regularly collected health data: a systematic review. Alzheimer’s dementia. 141038-1051 (2018).

    Article PubMed Google Scholar

  • Lin, PJ et al. Disparities in dementia diagnosis by race and ethnicity: Health services research: Cost of care and implications for intervention. Alzheimer’s dementia. 16e043183 (2020).

    Google Scholar article

  • Office of the Assistant Secretary for Planning and Evaluation. U.S. Department of Health and Human Services. National plan to combat Alzheimer’s disease. https://aspe.hhs.gov/collaborations-committees-advisory-groups/napa/napa-documents/napa-national-plan (2023).

  • Wright, JD et al. The ARIC (Atherosclerosis Risk in Communities) study: JACC Focus seminar 3/8. Jam. Coll. Cardiol. 772939-2959 (2021).

    Article PubMed PubMed Central Google Scholar

  • Knopman, DS et al. Mild cognitive impairment and prevalence of dementia: the risk of atherosclerosis in the neurocognitive community study. Alzheimer’s dementia. (Amst.) 21-11 (2016).

    Article PubMed Google Scholar

  • Knopman, DS et al. Cognitive domain abnormality models improve discrimination in dementia risk prediction: the ARIC study. Alzheimer’s dementia. 204559-4571 (2024).

  • Schneider, AL et al. Normative data from 8 neuropsychological tests performed on black and white older adults from the Atherosclerosis Risk in Communities (ARIC) study. Alzheimer’s disease. Assoc. Mess. 2932-44 (2015).

    Article CAS PubMed PubMed Central Google Scholar

  • Morris, JC The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 432412-2414 (1993).

  • Folstein, MF, Folstein, SE & McHugh, PR “Mini-mental state”: a practical method for assessing the cognitive state of patients for the clinician. J. Psychiatrist. Res. 12189-198 (1975).

    Article CAS PubMed Google Scholar

  • Pfeffer, RI, Kurosaki, TT, Harrah, C. Jr, Chance, JM and Filos, S. Measuring functional activities in older adults in the community. J. Gerontol. 37323-329 (1982).

    Article CAS PubMed Google Scholar

  • Blessed, G., Tomlinson, BE & Roth, M. The association between quantitative measures of dementia and senile change in cerebral gray matter of elderly subjects. Brother. J. Psychiatry 114797-811 (1968).

    Article CAS PubMed Google Scholar

  • McKhann, GM et al. Diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging – Alzheimer’s Association working groups on guidelines for the diagnosis of Alzheimer’s disease. Alzheimer’s dementia. 7263-269 (2011).

    Article PubMed Google Scholar

  • Brandt, J., Spencer, M. and Folstein, M. The telephone interview for cognitive status. Neuropsychiatry Neuropsychol. Behavior. Neurol. 1111-117 (1988).

    Google Scholar

  • Callahan, CM, Unverzagt, FW, Hui, SL, Perkins, AJ & Hendrie, HC Six-item screener for identifying cognitive impairment among potential clinical research subjects. Med. Care 40771-781 (2002).

    Article PubMed Google Scholar

  • Lin, D. Nonparametric inference for cumulative incidence functions in competing risk studies. Stat. Med. 16901-910 (1997).

    3.0.CO;2-M” data-track-item_id=”10.1002/(SICI)1097-0258(19970430)16:83.0.CO;2-M” data-track-value=”article number” data-track-action=”article number” href=”https://doi.org/10.1002%2F%28SICI%291097-0258%2819970430%2916%3A8%3C901%3A%3AAID-SIM543%3E3.0.CO%3B2-M” aria-label=” Item reference 43″ data-doi=”10.1002/(SICI)1097-0258(19970430)16:83.0.CO;2-M”>CAS article PubMed Google Scholar

  • Statistical Documentation 18. https://www.stata-press.com/manuals/documentation-set/

  • newsnetdaily

    Share
    Published by
    newsnetdaily

    Recent Posts

    NFL legend, Terry Bradshaw, 76

    By Isabel Baldwin and Daniel Matthews Posted: 20:26 HAE, April 11, 2025 | Update: 20:26…

    1 minute ago

    San Jose Sharks lose against Edmonton’s Oilers, Connor McDavid

    Friday evening, the San Jose Sharks could not remain outside the penalty box against the…

    2 minutes ago

    The military judge throws the confession of the cases of September 11 as obtained by torture

    Friday, a military judge threw the confession that a man accused of conspiracy in the…

    8 minutes ago

    Trump Administration News: The judge requires daily updates to efforts to wrongly return the expelled man

    An immigration judge in Louisiana noted on Friday that the Trump administration could expel Mahmoud…

    9 minutes ago

    Trump’s prices to cost us $ 108 billion car manufacturers; Ford, GM, Stellantis hit hard

    President Trump's rigid prices on foreign automobile imports will cost car manufacturers of nearly $…

    10 minutes ago

    WWE Books Street & Andre Battle Royal profits title match on Wrestlemania Smackdown

    There were a few rumors this week about the champions of the WWE Tag team,…

    11 minutes ago