The caffeine levels in your blood could affect the amount of body fat you wear, a factor that could in turn determine your risk of developing type 2 diabetes and cardiovascular disease.
It was the results of a 2023 study that used genetic markers to establish a more final link between caffeine levels, BMI and the risk of type 2 diabetes.
The research team, of the Karolinska Institute in Sweden, the University of Bristol in the United Kingdom and the Imperial College of London in the United Kingdom, said that caffeinated fires without calories could be explored as a potential means of Reduce body fat levels.
“Genetically predicted concentrations of more predicted plasma caffeine were associated with a fatty mass of the BMI and the whole body,” wrote the researchers in their article, published in March 2023.
“In addition, the genetically predicted concentrations of more predicted plasma caffeine were associated with a lower risk of diabetes type 2. approximately half of the caffeine effect on the responsibility of type 2 diabetes was estimated at mediation by reduction of BRI. “
The study involved data of just under 10,000 people collected in existing genetic databases, focusing on variations in specific genes or near specific specific to be associated with the speed at which caffeine is decomposed.
In general, those with variations affecting genes – namely Cyp1a2 and a gene that regulates it, called Ahr – Try to decompose caffeine more slowly, which allows him to stay in blood longer. However, they also tend to drink less caffeine in general.
An approach called Mendelian randomization was used to determine the probable causal relationships between the presence of variations, diseases such as diabetes, body mass and lifestyle.
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Although there is a significant link between caffeine levels, BMI and the risk of type 2 diabetes, no relationship has appeared between the amount of caffeine in the blood and cardiovascular diseases, especially atrial fibrillation , heart failure and cerebral vascular accidents.
Previous studies have linked a moderate and relative increase in caffeine consumption for better heart health and a lower BMI, and this research adds more details to what we already know on the effects of coffee on the body.
It is important to keep in mind that the impacts of caffeine on the body are not all positive, which means that care must be taken in terms of weighing the advantages of drinking it – but the latter study is a step important to assess the ideal amount of caffeine.
“Small short -term trials have shown that caffeine intake causes weight and reduction in fat, but the long -term effects of caffeine intake are unknown,” the researchers said.
“Given the in -depth consumption of caffeine in the world, even its small metabolic effects could have significant health implications.”
The team thinks that the association shown here could be due to the way caffeine increases thermogenesis (heat production) and oxidation of fats (transform fat into energy) in the body, which both play a role important in global metabolism.
Although this study involved a large sample, Mendelian randomization is not infallible, and it is always possible that other factors are at stake that were not taken into account. Additional research will be necessary to confirm the cause and the effect.
“Randomized controlled trials are justified to assess whether drinks containing non -calorie caffeine could play a role in reducing the risk of obesity and type 2 diabetes,” said Benjamin Woolf, genetic genetic epidemiologist de Bristol.
Research was published in BMJ medicine.
A previous version of this article was published in March 2023.
