Elsewhere on the seeding list, 10-time champion Novak Djokovic is No.7, the Serb targeting an all-time record 25th Grand Slam singles title.
Another trophy at Melbourne Park would see him draw level with Australian Margaret Court for the most AO singles titles in history, on 11.
Speaking of Aussies, three Australians – Alex de Minaur, Alexei Popyrin and Jordan Thompson – are seeded at the same Grand Slam tournament for the first time in 25 years.
The last time that happened was Wimbledon in 2000, when the seeded Australian players were Lleyton Hewitt, Mark Philippoussis and Pat Rafter.
The most humble No.1 🙏
Pat Rafter joins The Sit-Down to speak about his illustrious career 👉🎧 https://t.co/Jdq8pJfQdh pic.twitter.com/WMA9GGEUvt
— #AusOpen (@AustralianOpen) January 6, 2025
The last time it happened in men’s singles in Melbourne was 43 years ago at Australian Open 1982, in the tournament’s Kooyong days.
Djokovic and Sinner are the only players on the 2025 seed list to have previously won the Australian Open title. Among the women, the other former champion on the list is 21st seed Victoria Azarenka.
No.3 seed Carlos Alcaraz has the opportunity to complete the career Grand Slam at Melbourne Park.
An AO title would see the Spaniard – the reigning Roland Garros and Wimbledon champion – become the youngest man in tennis history to have won all four major singles titles.