Summary: A new study reveals that acetate, when associated with specific intestinal bacteria, can considerably reduce the mass of fat and liver in normal and obese mice. The researchers used a supplement called Acecel, which delivers acetate directly to the large intestine, promoting the growth of bacteria of bacteroides.
This combination stimulates the combustion of fats on the use of carbohydrates and decreases the absorption of sugar, imitating the metabolic effects observed in states on an empty stomach or ketogenic. Above all, these advantages have disappeared when the bacteroides were absent, confirming that the chemical and microbial conditions are necessary for the effect.
Key facts:
- Acecel + Bacteroides: Weight loss effects only occur when acetate reaches colon And Bacteroid species are present.
- Metabolic shift: Promotes the combustion of fats on the combustion of sugar, similar to fasting or keto.
- Intestinal mechanism: Bacteria ferment more carbohydrates, reducing the absorption of sugar and the storage of liver fats.
Source: Riken
Researchers led by Hiroshi Ohno at the Riken Center for Integrative Medical Sciences (IMS) in Japan have discovered a new way of reducing obesity.
Their study shows that feeding the intestine with additional acetate reduces the mass of fat and liver in normal and obese mice, as long as bacteria in the Bacteroides The species are also present in the intestine.
When these two conditions are met, intestinal bacteria can eliminate more intestine sugars and promote fat burns for energy in the host.
The results were published in the scientific journal Cellular metabolism.
Affecting hundreds of millions of people around the world, obesity is a global epidemic. It is linked to eating too much sugar and almonds and is known to increase the risk of heart disease, type 2 diabetes and cancer.
At the same time, studies show that the consumption of fibers reduces the risk of these same diseases, even if it cannot be digested directly by mammals.
When the fiber reaches your intestine – the large intestine to be precise – it is fermented by bacteria and by -products are released in the light of the intestine, some of them making blood circulation.
The most common of these by-products is acetate, which is known to have beneficial effects on the metabolism of the host. Although this makes dietary fiber a good “prebiotic”, the individual variation in the production of acetate and other useful by-products limits its effectiveness.
To get around this problem, Ohno and his team previously developed a kind of acetate supplement by combining it with cellulose. Acecel guarantees that acetate reaches the big distal intestine where it can work its magic.
In the new study, the team studied how the ACECEL affects mouse metabolism and the composition of intestinal bacteria. They found that when they gave them acecel, normal and obese mice lost weight without losing muscle mass.
It was not true for the other by-products of short-chain fatty acid, which means that acetate itself is the key. Other tests were designed to understand how it was.
They then discovered that compared to the mice with a normal diet, when mice fed at the Acecel were resting, they generated more energy from burning liver fat and less from burning carbohydrates. This is similar to what is happening when fasting or on a low carbohydrate, keto and promotes weight loss.
Employing that the effects on the intestinal microbiome would also be similar, they analyzed the intestine microbiota BacteroideS bacteria in their guts.
They then tested ACECEL in mice who had an intestine microbiota BacteroideS species. They found that the Acecel had no effect on the body, the liver or the fat mass in the free mice of the intestine, while three BacteroideSpecies S had similar positive effects on each.
This means that the specific combination of acetate and BacteroideBacteria in the intestines are necessary for the weight loss observed to occur.
By digging more deeply, they found that this combination leads to more fermentation of carbohydrates in the intestine, which means that there is less sugar available for the host.
By eliminating sugars, the energy derived from fats is favored and less sugar is stored in the form of glycogen in the liver, thus explaining how obesity is reduced.
“The development of a treatment or prevention strategy for obesity is an urgent problem that must be solved quickly,” explains Ohno.
“We have found that acetylated cellulose can prevent obesity by modulating the function of the intestinal microbiome.”
“Our next step is to confirm the safety and effectiveness of the use of acetylated cellulose to treat obesity in humans. If this is the case, it could become an important ingredient in functional foods that prevent obesity. ”
About this new research on obesity
Author: Adam Phillips
Source: Riken
Contact: Adam Phillips – Riken
Picture: The image is credited with Neuroscience News
Original search: Open access.
“Acetylated cellulose removes body mass gain thanks to intestinal comments consuming carbohydrates accessible to the host” by Hiroshi Ohno et al. Cellular metabolism
Abstract
Acetylated cellulose removes body mass gain thanks to intestinal commensals consuming carbohydrates accessible to the host
Effective approaches to prevent and deal with obesity are necessary urgently.
Although current strategies focus mainly on the direct modulation of host’s metabolism, another promising approach may involve limiting the availability of nutrients thanks to the regulation of the intestinal microbiota, which links the diet and the physiology of the host.
Here, we report that acetylated cellulose (Acecel), which considerably modifies the composition and the intestinal bacterial function, reduces body mass gain in wild and obese mice.
ACECEL limits the oxidation of carbohydrates and promotes oxidation of fatty acids in the host of the host in a manner dependent on the microbiota.
We also show that acetate improves the fermentation of carbohydrates by the intestine as Bacteroides ThétaIotaomicronExhausting simple sugars accessible to the host in the intestine of mice fed at the Acecel.
These results highlight the potential of the ACECEL as a prebiotic which regulates the metabolism of carbohydrates in bacteria and the host, offering a promise as therapeutic strategy for obesity.
