Two NFC heavyweights will face off when the Washington Commanders take on the Detroit Lions in an NFL Divisional Round game on Saturday. Washington is coming off a last-second 23-20 victory over the Tampa Bay Buccaneers in the Wild Card round, while Detroit is coming off a bye after dismantling the Minnesota Vikings, 31- 9, in Week 18. The Commanders (12-5), who earned the sixth seed in the 2025 NFL playoff bracket by placing second in the NFC East, have a 6-3 record on the road, including the playoffs. The Lions (15-2), top seed in the NFC after winning the North Division, are 7-2 on their home field. The audience is split evenly between the pluses and minuses, while more than two-thirds of the money ends up in the lower categories.
Kickoff from Ford Field in Detroit is scheduled for 8 p.m. ET. Detroit is a 9.5-point favorite in the latest Commanders vs. Lions odds, while the over/under in total points scored is 55.5. Detroit is a -498 favorite (risk $498 to win $100), while Washington is a +376 underdog. Before making any Commanders vs. Lions picks, be sure to check out the NFL predictions and betting advice from SportsLine expert Larry Hartstein, given his mastery of picks involving Washington.
A former senior editor at Covers and The Linemakers, Hartstein combines an extensive network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. He finished tied for 52nd place (out of 1,598 entries) at the 2022 Westgate Las Vegas SuperContest, with a 53-34-3 ATS record. Hartstein’s weekly Vegas contest selections form the basis of his NFL Best Bets column, which is 79-48-2 (62.2%, +25.95 units) since its inception in 2022. He also an incredible 19-5 (+1312) in his last match. 24 NFL picks on Commanders. Anyone who follows sports betting and betting apps could have seen huge returns.
Now Hartstein has focused on Commanders vs. Lions and just revealed his coveted NFL picks and predictions. You can head over to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines for the Commanders vs. Lions:
Veteran quarterback Jared Goff fuels Detroit’s offense. In 17 starts, he completed 390 of 539 passes (72.4%) for 4,629 yards and 37 touchdowns with 12 interceptions and a rating of 111.8. In the regular season finale against Minnesota, he was efficient, completing 27 of 33 passes (81.8%) for 231 yards, one touchdown and two interceptions.
His top target is veteran wide receiver Amon-Ra St. Brown. In 17 games, St. Brown has caught 115 passes for 1,263 yards (11.0 average) and 12 touchdowns. He had 14 explosive plays of 20 yards or more, including a long of 66, with 412 yards after the catch and 72 first-down conversions. Find out who to support on SportsLine.
Rookie quarterback Jayden Daniels guided Washington to its first playoff victory since 2005 with a victory over Tampa Bay in the Wild Card round. In that game, Daniels completed 24 of 35 passes (68.6%) for 268 yards and two touchdowns with a rating of 110.2. He also rushed 13 times for 36 yards. In 17 regular season games, Daniels led the Commanders in rushing and passing. He completed 69% of his passes for 3,568 yards and 25 touchdowns with nine interceptions and a rating of 100.1. He also carried 148 times for a team-high 891 yards (6.0 average) and six touchdowns.
Receiver Terry McLaurin is his main target. In the win against the Buccaneers, he caught seven passes for 89 yards and a touchdown. In 17 regular season games, McLaurin caught 82 passes for 1,096 yards (13.4 average) and 13 touchdowns. He had 12 explosive plays of 20 yards or more, including a long of 86, with 56 first-down conversions. Find out who to support on SportsLine.
Hartstein has analyzed Lions vs. Commanders from every possible angle, and while we can tell you he’s leaning on the total, he’s also discovered a critical X-factor that has him jumping to one side of the spread. Find out what it’s all about and which team to support on SportsLine.
So who wins the Lions against the Commanders on Saturday during the 2025 NFL Wild Card Weekend, and what critical X-factor causes one side of the spread to be hit hard? Visit SportsLine now to see which way the Lions vs. Commanders have spread, all from the expert who is an incredible 19-5 on picks involving Washington, and find out.
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