2025 CFP National Championship Game Odds, Notre Dame vs. Ohio State Expert Picks: Parlay Returns Nearly +300

The College Football Playoff has grown from four teams to 12 this season and now, an exciting postseason will culminate with the 2025 College Football Playoff National Championship Game on Monday, January 20 at 7:30 p.m. ET. Ohio State posted wins of 14 points or more over Tennessee, Oregon and Texas to advance to the title game, while Notre Dame beat Indiana, Georgia and Penn State on its way. Now, these college football powerhouses will face off with a chance for history on the line after facing each other in the regular season for the past two years.

The latest CFP National Championship Game odds via SportsLine consensus list Ohio State as an 8.5-point favorite against Notre Dame while the over/under is 46.5, up a half-point from in the first match. The Buckeyes are -368 (risk $368 to win $100) on the money line, while the Fighting Irish are +289 (risk $100 to win $289). Before you lock in the College Football Playoff National Championship game picks, be sure to check out Thomas Casale’s top gaming expert picks for the CFP title, predictions and best bets.

A frequent guest on national radio and television shows to discuss college sports, Casale has been betting on sports – and winning – for more than 30 years. Dating back to Week 13 of the regular season, he is 14-7 in his best bets column, including a perfect 3-0 week late in the season that landed a +600 parlay. Anyone who followed these picks could have seen huge returns.

Now, he’s turned his attention to the CFP bracket and college football third-round odds and shares his top two betting picks. If you exploit these college football betting picks, you could be looking at a return of almost +300. Get his best college football picks at SportsLine.

Best College Football Playoff Predictions From Experts

One of Casale’s top picks for the College Football Playoff: He’s playing under 46.5 points for the 2025 CFP national title game. These were the two best defenses in the country this season, with Ohio State allowing 12 .2 points per game and Notre Dame allowing 14.3 points per game. Even against strong playoff competition, Notre Dame only allowed 17 points per game while Ohio State allowed 17.3 points per game.

Both teams have also held opponents to fewer than 300 yards per game and allowed fewer than 170 yards per game through the air this season. With almost two full weeks to prepare for each other, you can expect Marcus Freeman and Jim Knowles to have their defensive units well prepared. Casale also expects a broken Notre Dame offense to contribute to a low-scoring battle.

“The Irish lost two starters on the offensive line against Penn State when left tackle Anthonie Knapp and right guard Rocco Spindler were injured,” Casale told SportsLine. “Credit to Notre Dame running back Jeremiah Love for knocking him out in the semifinals, but he’s clearly not 100 percent either. It’s hard enough running on a defense ‘Ohio State allowing just 92.6 yards per game on the ground It’ll be even tougher for Notre Dame, with Love still nursing a knee injury he suffered against Indiana » Find out what else. choice Casale likes on SportsLine.

How to Make College Football Playoff Picks

Casale also has a must-win pick for the 2025 College Football Playoff national championship game, where he likes a team to use a lower-scoring game to their advantage. You can only see his picks on SportsLine.

What are the best bets for the 2024-25 College Football Playoff National Championship? Visit SportsLine now to see Thomas Casale’s best college football bets, all from a proven college football handicapper who has gone 26-8 in bowl games over the past two seasons and 14-7 on the best bets since week 13, and find out.